Published evidences
Clinical publications
HYALOFAST®, the only 100% hyaluronic acid-based scaffold, has excellent clinical data to support its use in the treatment of chondral and osteochondral lesions with the regeneration of hyaline like cartilage. The positive results achieved with HYALOFAST enable patients to return to their daily activities naturally.
Below are the main clinical papers showing the HYALOFAST’s superior cartilage regeneration ability in knee and ankle joints.
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KNEE
Clinical evidences for the use of Hyalofast + BMAC
Excellent clinical and MRI results at short and medium term also in OCD patients
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Buda R, et al. Osteochondral lesions of the knee: a new one-step repair technique with bone-marrow-derived cells. J Bone Joint Surg Am. 2010 Dec
Buda R. et al. One-step arthroscopic technique for the treatment of osteochondral lesions of the knee with bone-marrow-derived cells: three years results. Musculoskelet Surg. 2013 Feb
Vannini F. et al. One Step Treatment of Juvenile Osteochondritis Dissecans in the Knee: clinical results and T2 mapping Characterization. Orthop Clin N Am, 2012
Gobbi A., et al. One-Stage Cartilage Repair Using a Hyaluronic Acid-Based Scaffold With Activated Bone Marrow-Derived Mesenchymal Stem Cells Compared With Microfracture: Five-Year Follow-up. Am J Sports Med. 2016 Nov.
Gobbi A., et al. One-step surgery with multipotent stem cells and Hyaluronan-based scaffold for the treatment of full-thickness chondral defects of the knee in patients older than 45 years. Knee Surg Sports Traumatol Arthrosc, 2017
Hyaline-like cartilage regeneration confirmed by 2nd look biopsies and/or arthroscopies and/or MRI T2 mapping
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Buda R, et al. Osteochondral lesions of the knee: a new one-step repair technique with bone-marrow-derived cells. J Bone Joint Surg Am. 2010 Dec.
Buda R. et al. One-step arthroscopic technique for the treatment of osteochondral lesions of the knee with bone-marrow-derived cells: three years results. Musculoskelet Surg. 2013 Feb.
Vannini F. et al. One Step Treatment of Juvenile Osteochondritis Dissecans in the Knee: clinical results and T2 mapping Characterization. Orthop Clin N Am, 2012.
Gobbi A. et al. Matix-Induced Autologous Chondrocyte Implantation versus Multipotent Stem Cells for the treatment of large patellofemoral chondral lesions: a non randomized prospective trial. Cartilage, 2014 Dec.
Gobbi A., et al. One-step surgery with multipotent stem cells and Hyaluronan-based scaffold for the treatment of full-thickness chondral defects of the knee in patients older than 45 years. Knee Surg Sports Traumatol Arthrosc, 2017.
Effective treatment for large patellofemoral chondral defects with results stable up to medium term
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Gobbi A. et al. Matix-Induced Autologous Chondrocyte Implantation versus Multipotent Stem Cells for the treatment of large patellofemoral chondral lesions: a non randomized prospective trial. Cartilage 2014 Dec.
Buda et al. A useful combination for the treatment of patellofemoral chondral lesions: realignment procedure plus mesenchymal stem cell-retrospective analysis and clinical results at 48 months follow-up. Eur J Orthop Surg Traumatol. 2019 Feb.
Effective treatment for large knee chondral defects in patients over 45 years with results stable up to medium term follow-up
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Gobbi A., et al. One-step surgery with multipotent stem cells and Hyaluronan-based scaffold for the treatment of full-thickness chondral defects of the knee in patients older than 45 years. Knee Surg Sports Traumatol Arthrosc, 2017.
Clinical results at medium-term follow-up superior to microfracture alone
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Gobbi A., et al. One-Stage Cartilage Repair Using a Hyaluronic Acid-Based Scaffold With Activated Bone Marrow-Derived Mesenchymal Stem Cells Compared With Microfracture: Five-Year Follow-up. Am J Sports Med. 2016 Nov.
Clinical results equivalent to matrixinduced ACI (MACI) at medium term follow-up
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Gobbi A. et al. Matix-Induced Autologous Chondrocyte Implantation versus Multipotent Stem Cells for the treatment of large patellofemoral chondral lesions: a non randomized prospective trial. Cartilage 2014 Dec.
Good to excellent clinical outcomes in cartilage lesions of the knee at long-term follow-up
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Gobbi A et al. Long-term Clinical Outcomes of One-Stage Cartilage Repair in the Knee With Hyaluronic Acid-Based Scaffold Embedded With Mesenchymal Stem Cells Sourced From Bone Marrow Aspirate Concentrate. Am J Sports Med. 2019 May 16
Buda R et al. Osteochondral Lesions of the Femoral Condyles: Are the Results of the One-Step Repair Technique Still Satisfactory at Longterm? Abstract ISAKOS congress 12-15 May 2019
Clinical evidences for the use of Hyalofast + MFX
Good clinical and MRI outcomes superior to microfracture alone at short term follow-up
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Sofu A., et al. Results of Hyaluronic Acid-Based Cell-Free Scaffold Application in Combination With Microfracture for the Treatment of Osteochondral Lesions of the Knee: 2-Year Comparative Study. Arthroscopy 2017 Jan
ANKLE
Clinical evidence for the use of Hyalofast + BMAC
Excellent clinical and MRI results at short and medium term in osteochondral ankle defects
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Giannini S. et al. One step Bone Marrow-derived cell Transplantation in Talar Osteochondral Lesions. Clin Orthop Relat Res, Dec; 467 (12):3307-20.
Battaglia M, et al. Validity of T2 mapping in characterization of the regeneration tissue by bone marrow derived cell transplantation in osteochondral lesions of the ankle. Eur J Radiol. 2011 Nov; 80(2):132-9
Giannini S, et al. Cartilage repair evolution in post-traumatic osteochondral lesions of the talus: From open field autologous chondrocyte to bone-marrow-derived cells transplantation. Injury, 2010 Nov.
Buda R., et al. Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus onestep bone marrow derived cells transplantation. International Orthopaedics (SICOT) 2015.
Hyaline-like cartilage regeneration confirmed by 2nd look biopsies and/or arthroscopies and/or MRI T2 mapping
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Giannini S. et al. One step Bone Marrow-derived cell Transplantation in Talar Osteochondral Lesions. Clin Orthop Relat Res, Dec; 467 (12):3307-20.
Battaglia M, et al. Validity of T2 mapping in characterization of the regeneration tissue by bone marrow derived cell transplantation in osteochondral lesions of the ankle. Eur J Radiol. 2011 Nov; 80(2):132-9.
Giannini S, et al. Cartilage repair evolution in post-traumatic osteochondral lesions of the talus: From open field autologous chondrocyte to bone-marrow-derived cells transplantation. Injury, 2010 Nov.
Buda R., et al. Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus onestep bone marrow derived cells transplantation. International Orthopaedics (SICOT) 2015.
Tahta M et al. Arthroscopic treatment of osteochondral lesions of the talus: nanofracture vs Hyaluronic acid-based cell-free scaffold with concentration of autologous bone marrow aspirate. J Orthop Surg 25(2): 1-5, 2017.
Clinical results at medium-term follow-up superior to nanofracture alone
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Tahta M et al. Arthroscopic treatment of osteochondral lesions of the talus: nanofracture vs Hyaluronic acid-based cell-free scaffold with concentration of autologous bone marrow aspirate. J Orthop Surg 25(2): 1-5, 2017.
Clinical results equivalent to matrix-induced ACI (MACI) at medium term follow-up
show clinical references
Giannini S, et al. Cartilage repair evolution in post-traumatic osteochondral lesions of the talus: From open field autologous chondrocyte to bone-marrow-derived cells transplantation. Injury, 2010 Nov.
Buda R., et al. Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus onestep bone marrow derived cells transplantation. International Orthopaedics (SICOT) 2015.