Authors: Grigolo B., Lisignoli G., Desando G., Cavallo C., Marconi E., Toschon M., Giavaresi G., Fini M., Giardino R., Facchini A.
Bibl. Ref.: TISSUE ENG PART C Volume 15, Number 4, 2009 (647-658)
Summary: An in vivo experiment in a rabbit osteoarthritis model was performed. The surgical osteoarthritis model was based on anterior cruciate ligament transaction (ACLT). Upon surgery animals were divided into 4 groups: sham operated, ACLT, ACLT – Hyalofast® only and ACLT- Hyalofast® with MSCs. After 3 and 6 months, histomorphometrical and immunohistological evaluations were performed. Data showed that MSCs seeded on Hyalofast® can positively interfere with osteoarthritis progression. It has to be noted that, in this model, in the scaffold only group there is no access to the subchondral bone, therefore no MSC population could come in contact with the lesion area. Results show statistically significant influence of the MSC-loaded Hyalofast® on disease progression by the formation of cartilaginous tissue at the site of the lesion.
Credit line: PubMed – View abstract